The Kentucky Derby Festival Marathon is described as "mostly flat," and for the first 10 miles and the last 10 miles, that's accurate. But miles 10 through 15 run through Iroquois Park, part of Louisville's Olmsted-designed park system (the same Frederick Law Olmsted who designed Central Park), and those 5 miles are a different race entirely.
Iroquois Park sits on a hill in Louisville's South End, and the marathon course takes you up, through, and around it. The terrain rolls constantly: climbs of 2 to 4% grade followed by descents that don't fully return the elevation, then more climbing. There's a particularly steep down-and-up section in the middle of the park where runners have described the effort as "brutal." The park roads wind through turns and switchbacks under a tree canopy, which provides welcome shade but limits your ability to see how much climbing remains ahead.
The Iroquois Park section is what separates the full marathon from the miniMarathon. Half marathon runners don't go through the park. Full marathon runners do, and it's the reason the marathon has a 5 to 7% BQ rate while the half marathon course is considered fast and flat. The hills aren't Heartbreak Hill or Hurricane Point in terms of individual intensity, but their placement at miles 10 through 15, right in the middle of the race, means you have to run the second half of your marathon on legs that just absorbed 5 miles of rolling parkland.
Multiple runners have recommended running the Louisville 10 Miler as training, because that course follows the same path down Southern Parkway and through the park. If you can preview the Iroquois Park section on your legs before race day, you'll know exactly what to expect and can calibrate your pacing accordingly.
The advice from experienced Derby Marathon runners is consistent: save energy for the park. Don't go out fast in the flat opening miles. When you enter Iroquois Park, run by effort, not pace. Let the hills come to you. Use the shade and the winding roads to stay relaxed. And know that when you emerge from the park, the rest of the course is flat or gentle, and you can begin to press again.