The Knoxville Marathon gains approximately 1,300 feet of total elevation over 26.2 miles. The max elevation on the course is around 917 feet, the minimum is around 821 feet, and you start and finish at roughly the same spot in downtown Knoxville. On paper, none of these numbers look intimidating. In practice, this is one of those courses where the elevation profile tells half the story and your legs tell the rest.
Here's why: the course is almost never flat. The profile looks like a saw blade, not a mountain. There are no massive single climbs (nothing resembling Hurricane Point at Big Sur or Heartbreak Hill in Boston), but there is a relentless succession of 20 to 60 foot rollers that prevent you from ever fully settling into a locked-in rhythm. The race website's FAQ says "the total elevation change is not dramatic, but there are not very many miles that are just flat." That's probably the most honest thing a race website has ever said about its own course.
The hills are front-loaded. The first 13 miles, which take you through the UT campus, down Neyland Drive, out through Kingston Pike, and into the Sequoyah Hills neighborhood, contain the most significant elevation changes. The climb up Noelton Drive, somewhere around mile 8 to 9, is generally considered the steepest sustained grade on the course. Multiple runners have flagged it as the one hill that genuinely surprised them. The rolling terrain through the Sequoyah Hills loop and back along Third Creek Greenway keeps the quads working through the entire first half.
The second half is a different course. After the half marathon split at World's Fair Park, the marathon route heads north and east through the Fourth and Gill and Parkridge neighborhoods, then south across the South Knoxville Bridge into the Island Home area. This section has gentler terrain, longer riverside stretches, and a net-downhill trend as you return to downtown for the finish. Runners consistently describe the second half as more forgiving than the first.
If you are targeting a negative split (and on this course, you should be), the elevation profile is actually your friend. The harder terrain is early, when your legs are fresh, and the easier terrain is late, when you need it most. The mistake is running the flat-feeling first two miles at an aggressive pace, getting punched by the Noelton Drive climb, and spending the rest of the first half in damage control. Treat the opening 13 miles as the setup. The second half is where you run your time.
One note on GPS accuracy: several runners have reported their watches measuring the course slightly long (26.4 to 26.6 miles). This is common on urban loop courses with lots of turns and is not a certification issue. But it does mean your mile splits may look slightly off in the final analysis.